Adenosine Receptor
The adenosine receptors (P1 receptors) are a class of purinergic G protein-coupled receptors with adenosine as endogenous ligand. In humans, there are four types of adenosine receptors(A1,A2A ,A2B,A3). Each is encoded by a separate gene and has different functions, although with some overlap. For instance, both A1 receptors and A2A play roles in the heart, regulating myocardial oxygen consumption and coronary blood flow, while the A2A receptor also has broader anti-inflammatory effects throughout the body. These two receptors also have important roles in the brain, regulating the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors are located mainly peripherally and are involved in processes such as inflammation and immune responses.
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BAY 60-6583是活性的 A2B 受体 激动剂， 心血管保护活性。
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5-Iodotubercidin是活性的 adenosine 激酶抑制剂， 也抑制 核苷转运蛋白和其他的激酶。
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2'-MeCCPA是高选择性的活性 A1 受体 激动剂。
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2-Cl-IB-MECA是高选择性 A3 激动剂。
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1-Deazaadenosine是Adenosine deaminase 抑制剂。
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